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A novel transformer-based approach for cardiovascular disease detection
Nimra Noor1, Muhammad Bilal1, Saadullah Farooq Abbasi2
1Department of Artificial Intelligence, Rare Sense Inc, Covina, CA, United States.
Frontiers in Digital Health
|May 14, 2025
Summary
A new transformer algorithm accurately classifies cardiovascular diseases (CVDs) using electrocardiography data. This efficient, low-cost method shows high performance, aiding early CVD prediction and reducing mortality.
Area of Science:
- Biomedical Engineering
- Artificial Intelligence in Healthcare
- Cardiology
Background:
- Cardiovascular diseases (CVDs) are a leading cause of global mortality, accounting for 17.9 million deaths annually.
- Early detection of CVDs, including arrhythmia and heart failure, is crucial for reducing mortality rates.
- Existing diagnostic methods require improvement in efficiency and cost-effectiveness for widespread application.
Purpose of the Study:
- To develop a novel, efficient, and low-cost transformer-based algorithm for the classification of cardiovascular diseases.
- To enhance the early prediction capabilities for various CVDs using electrocardiography (ECG) data.
- To evaluate the performance of the proposed algorithm against existing state-of-the-art methods.
Main Methods:
- Extraction of 56 features from 1,200 ECG records representing four distinct cardiovascular diseases.
- Application of Random Forest for feature selection, identifying the 13 most significant features.
- Development and implementation of a novel transformer-based algorithm for classifying the four CVD classes.
Main Results:
- The proposed transformer algorithm achieved exceptional classification performance.
- Maximum accuracy reached 0.9979, with precision, recall, and F1 scores all exceeding 0.9958.
- The algorithm demonstrated superior performance compared to all previously reported state-of-the-art CVD classification methods.
Conclusions:
- The developed transformer-based algorithm offers a highly accurate and efficient solution for cardiovascular disease classification.
- This novel approach holds significant potential for improving early CVD detection and patient outcomes.
- The low-cost and efficient nature of the algorithm makes it suitable for broader clinical implementation.

