Stomach distension in extremely obese and in normal subjects

The maximal tolerable distension of the stomach was measured with a balloon system in 16 extremely obese and 11 normal-weight subjects. The mean maximal tolerated volume was significantly greater in the obese group (1763 +/- 70 vs. 1000 +/- 67 ml). The volume at which a satiety-simulating sensation appeared was likewise greater in the obese group (850 +/- 74 vs. 541 +/- 44 ml). The intragastric pressure originating from the stomach wall as such presumably was similar in both groups. The greater capacity for gastric distension in extremely obese persons may be an etiologic factor in the development of obesity or an adaptation to the eating pattern.