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Invasive Coronary Physiology Study in Multivessel Coronary Artery Disease

Agita Maryalda Zahidin1, Amir Aziz Alkatiri1, Arwin Saleh Mangkuanom1

  • 1Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|May 14, 2025
PubMed

Insights

Instantaneous wave-free ratio (iFR) offers a simpler, hyperemia-free method for assessing coronary stenosis severity. This case study demonstrates iFR-guided percutaneous coronary intervention (PCI) as a valuable tool for managing multivessel coronary artery disease (CAD).

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Physiology

Background:

  • Assessing coronary stenosis severity and its impact on blood flow is challenging due to limitations in coronary angiography.
  • Myocardial perfusion imaging by single-photon emission tomography (MPI-SPECT) aids intervention decisions but struggles with extensive coronary artery disease (CAD).
  • Fractional flow reserve (FFR) is the gold standard for evaluating the physiological significance of coronary stenosis.

Keywords:
instantaneous wave-free ratiomultivessel coronary artery diseasepercutaneous coronary interventionphysiology study

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