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KCNQ1 Polymorphism in the Context of Ischemic Cardiomyopathy: A Potential Key to Decision-Making for Device

Uğur Özkan1, Metin Budak2, Muhammet Gürdoğan1

  • 1Department of Cardiology, School of Medicine, Trakya University, Turkey.

Clinical Cardiology
|May 14, 2025
PubMed

Insights

Specific KCNQ1 gene variations (rs2237892 and rs2237895) are linked to ventricular tachyarrhythmia (VTA) in ischemic cardiomyopathy (ICM) patients. These genetic markers may aid in predicting VTA risk and guiding implantable cardioverter-defibrillator (ICD) decisions.

Area of Science:

  • Cardiovascular Genetics
  • Electrophysiology
  • Molecular Cardiology

Background:

  • Ventricular tachyarrhythmia (VTA) poses a significant risk in ischemic cardiomyopathy (ICM).
  • Genetic factors and electrical remodeling are key influences on VTA development in ICM.
  • Accurate risk stratification is crucial for managing VTA and guiding device implantation.

Purpose of the Study:

  • To investigate the association between KCNQ1 gene polymorphisms (rs2237892 and rs2237895) and VTA in ICM patients.
  • To evaluate the potential of these polymorphisms as biomarkers for VTA risk stratification.
  • To inform decisions regarding implantable cardioverter-defibrillator (ICD) implantation in ICM patients.

Main Methods:

  • A single-center study involving 213 ICM patients with ICDs for primary VTA prevention.
  • Genetic analysis of KCNQ1 polymorphisms (rs2237892, rs2237895) using real-time PCR.
  • Correlation and logistic regression analyses to assess the association between genotypes and VTA risk.

Main Results:

  • Patients with VTA showed significantly higher QT dispersion, frontal QRS-T angle, and T-wave peak-to-end interval.
  • The TT genotype of rs2237892 and AC genotype of rs2237895 were significantly associated with increased VTA risk (p < 0.001).
  • These KCNQ1 genotypes were confirmed as independent predictors of VTA in multivariate analysis.

Conclusions:

  • KCNQ1 gene polymorphisms rs2237892 and rs2237895 are strongly associated with VTA in ICM.
  • These polymorphisms may serve as valuable biomarkers for VTA risk stratification in ICM patients.
  • Findings can help personalize ICD implantation strategies and improve patient outcomes.
Abstract

Keywords:
KCNQ1 gene polymorphismimplantable cardioverter‐defibrillatorischemic cardiomyopathyventricular tachyarrhythmia

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