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Gentamicin-PMMA beads in the treatment of chronic osteomyelitis

S A Majid, L T Lindberg, B Gunterberg

    Acta Orthopaedica Scandinavica
    |June 1, 1985
    PubMed

    Insights

    This study treated chronic osteomyelitis using surgery, antibiotics, and gentamicin-PMMA beads. The treatment proved effective, with 39 out of 43 patients healing, demonstrating a successful approach to this bone infection.

    Area of Science:

    • Orthopedic Surgery
    • Infectious Diseases
    • Biomaterials

    Background:

    • Chronic osteomyelitis is a persistent bone infection requiring aggressive treatment.
    • Septic arthritis can complicate osteomyelitis, increasing treatment complexity.
    • Gentamicin-polymethylmethacrylate (PMMA) beads offer localized antibiotic delivery.

    Purpose of the Study:

    • To evaluate the efficacy of radical surgery combined with systemic antibiotics and gentamicin-PMMA beads for chronic osteomyelitis.
    • To assess treatment outcomes in patients with and without associated septic arthritis.

    Main Methods:

    • Retrospective analysis of 50 chronic osteomyelitis cases.
    • Treatment involved radical surgery, systemic antibiotics, and gentamicin-PMMA bead insertion.
    • Follow-up averaged 14 months for 43 cases.

    Main Results:

    • 39 out of 43 (90.7%) patients achieved healing.
    • Seven cases were lost to follow-up.
    • The combination therapy demonstrated high success rates in managing chronic osteomyelitis.

    Conclusions:

    • Radical surgery, systemic antibiotics, and gentamicin-PMMA beads are an effective treatment for chronic osteomyelitis.
    • This multimodal approach shows promise even in complex cases involving septic arthritis.
    • Further research could explore long-term outcomes and refine treatment protocols.

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