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Three-Dimensional-Printed Flexible Nanosilver Electrode Array for Parallel and Robust Intracellular

Keda Shi1,2,3, Liang Hu4, Duote Cai1

  • 1General Surgery Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou 310052, China.

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|May 14, 2025
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Summary

Researchers developed a 3D-printed flexible nanosilver electrode array (FlexNEA) for high-fidelity cardiac electrophysiology recordings. This advanced device improves intracellular access and drug screening for cardiovascular research.

Keywords:
3D-printed flexible nanosilver electrode arraydrug precise screeningintracellular electrophysiologymultimaterial 3D printingprimary cardiomyocyte electroporation

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Area of Science:

  • Cardiac electrophysiology
  • Biomedical engineering
  • Nanotechnology

Background:

  • Intracellular action potential (iAP) recordings are crucial for understanding and treating cardiovascular diseases.
  • Conventional electrodes face limitations in signal quality and ease of use for iAP recordings.

Purpose of the Study:

  • To develop a novel 3D-printed flexible nanosilver electrode array (FlexNEA) for enhanced cardiac electrophysiology.
  • To evaluate the FlexNEA's performance in intracellular access, signal quality, and drug screening applications.

Main Methods:

  • Utilized a multimaterial electric-field-driven (EFD) micro-jet 3D printing strategy for rapid electrode fabrication.
  • Employed electroporation for efficient and biosafe intracellular access.
  • Assessed cell-electrode coupling and signal fidelity compared to conventional electrodes.

Main Results:

  • Achieved over 99% success rate in intracellular access via electroporation.
  • Demonstrated superior signal quality due to enhanced cardiomyocyte-electrode coupling with the flexible NEA.
  • Enabled stable, high-fidelity intracellular recordings and accurate drug-induced iAP alteration detection for drug screening.

Conclusions:

  • The 3D-printed FlexNEA offers a significant advancement in high-fidelity intracellular recording for cardiac electrophysiology.
  • The integrated platform provides a precise, quantitative method for assessing ion-channel drug effects.
  • Presents a low-cost, biocompatible solution for preclinical cardiology and pharmacology research.