Comparison of Outcomes of Microsurgical Breast Reconstruction after Premastectomy and Postmastectomy Radiation...

This study compared complication rates and outcomes between patients who underwent premastectomy radiation therapy (Pre-MRT) followed by mastectomy with microsurgical immediate breast reconstruction (IMBR) and patients who underwent mastectomy followed by postmastectomy RT (PMRT) then microsurgical delayed breast reconstruction (DBR).

This is a secondary analysis of a randomized clinical trial (NCT02912312) that randomized patients with breast cancer to receive hypofractionated (40.05 Gy in 15 fractions) or conventionally fractionated (50 Gy in 25 fractions) regional nodal irradiation between August 2018 and August 2022. Demographic, treatment, and outcomes data were collected. The primary outcome was the rate of autologous flap loss. Secondary outcomes included rates of other recipient-site complications.

A total of 144 patients were included: 41 underwent Pre-MRT with IMBR and 103 underwent PMRT with DBR, including 66 patients who had tissue expander (TE) placement at the time of mastectomy and 37 who underwent total mastectomy. The median time from mastectomy to DBR was 12.8 months (interquartile range 9.7 to 16.3 months). There were no complete autologous flap losses in either group, and rates of other recipient-site complications were similar between the groups. Infection at the recipient site occurred in 20% (13 of 66) of patients in the PMRT group who underwent TE placement, and 9 (14%) required TE explantation because of complications.

Pre-MRT with microvascular IMBR is associated with a similar complication rate to PMRT with microvascular DBR while avoiding complications relating to TE placement and a reduced time to achieve definitive breast reconstruction. A larger randomized clinical trial of Pre-MRT followed by mastectomy and IMBR is currently underway (NCT05774678).