Amino Acid-Based Self-Assembled Supramolecular Structures: From Pathological Implications to Biomedical Applications

Area of Science:

• Biomolecular chemistry
• Nanotechnology
• Material Science

Background:

• Self-assembly is the spontaneous organization of molecules into supramolecular structures, mimicking natural biomolecules like DNA and proteins.
• The "FF" moiety's role in protein self-aggregation, particularly in amyloids, is crucial for peptide nanotechnology.
• Amino acids, as peptide building blocks, are fundamental to understanding and designing self-assembled nanomaterials.

Purpose of the Study:

• To systematically review recent findings on amino acid-based self-assembly.
• To discuss the pathological and functional roles of self-assembled amino acids and peptides.
• To highlight emerging applications of self-assembled amino acid-based nanomaterials in material science and biomedicine.

Main Methods:

• Literature review of recent findings on amino acid self-assembly.
• Systematic overview of self-assembly mechanisms and properties.
• Analysis of pathological and functional implications.

Main Results:

• Amino acid and peptide self-assembly leads to diverse supramolecular structures.
• Self-assembly has significant implications in biomedical fields like drug delivery, biosensing, and tissue engineering.
• The "FF" moiety is a key factor in self-aggregation, driving advancements in peptide nanotechnology.

Conclusions:

• Understanding amino acid self-assembly is vital for designing advanced functional materials.
• Self-assembled amino acid-based nanomaterials offer promising futuristic applications in material science and biomedicine.
• This review provides a comprehensive overview of the field, emphasizing its potential impact.