The undescribed alkaloids from Jacobaea cannabifolia (less.) E. Wiebe and their anti-inflammatory activities
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View abstract on PubMed
Summary
This summary is machine-generated.Researchers isolated new alkaloids from Jacobaea cannabifolia, with two compounds showing significant anti-inflammatory activity in cell studies. Further analysis confirmed their structures and configurations.
Area Of Science
- Natural Product Chemistry
- Pharmacology
Background
- Jacobaea cannabifolia (Less.) E. Wiebe is a plant source of bioactive compounds.
- Alkaloids are a diverse class of natural products with various pharmacological properties.
Purpose Of The Study
- To isolate and characterize chemical constituents from Jacobaea cannabifolia.
- To evaluate the anti-inflammatory potential of the isolated compounds.
Main Methods
- Phytochemical investigation involving isolation techniques.
- Structure elucidation using Nuclear Magnetic Resonance (NMR) spectroscopy and High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS).
- Absolute configuration determination via Electronic Circular Dichroism (ECD) analysis.
- Anti-inflammatory activity assay using lipopolysaccharide (LPS)-induced RAW 264.7 cells.
Main Results
- One new alkaloid, cannabliold E (1), and one new alkaloid derivative, methyl 4-(2-oxo-1-pyrrolidinyl) benzene acetate (2), were isolated.
- Seven known alkaloids (3-9) were identified.
- Compounds 6 and 8 demonstrated significant anti-inflammatory activity with IC50 values < 1.59 ± 0.18 μM.
Conclusions
- The study successfully identified novel and known alkaloids from Jacobaea cannabifolia.
- Compounds 6 and 8 possess notable anti-inflammatory properties, suggesting potential therapeutic applications.
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