Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DNA damage-associated vesicle production in <i>Stenotrophomonas maltophilia</i> is mediated by the maltocin endolysin.

Journal of bacteriology·2026

Same author

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026

Same author

Predicting Agitation Stability of Monoclonal Antibodies during Developability Assessment.

Molecular pharmaceutics·2026

Same author

Cationic mRNA Lipid Nanoparticles for Ex Vivo NanoCAR-T Cell Engineering.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Photodisruption of the Inner Limiting Membrane Promotes Retinal Engraftment of Stem-Cell Derived Retinal Ganglion Cells.

Investigative ophthalmology & visual science·2026

Same author

Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities.

Materials today. Bio·2026

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

Light-triggered nanocarriers for nucleic acid delivery.

Baihao Huang^1,2, Stefaan C De Smedt¹, Winnok H De Vos²

¹Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

|May 14, 2025

Summary

Light-triggered carriers offer a promising, biocompatible alternative for gene therapy delivery. These advanced systems enhance the efficiency of delivering therapeutic nucleic acids (NAs) into cells, overcoming key biological barriers for potential clinical applications.

Keywords:

Gene therapy intracellular barrier light-triggered delivery nucleic acid translational use

More Related Videos

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Related Experiment Videos

Last Updated: Jul 13, 2026

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Area of Science:

Biotechnology and Biomedical Engineering
Gene Therapy Delivery Systems
Nanomedicine

Background:

Gene therapy is a clinically validated approach for treating genetic disorders, cancer, and infectious diseases, with emerging roles in regenerative medicine.
Efficient and specific delivery of therapeutic nucleic acids (NAs) is critical for gene therapy success.
Existing viral and chemical delivery vectors present safety concerns and variable efficiencies, necessitating alternative solutions.

Purpose of the Study:

To review recent advancements in light-triggered nucleic acid delivery carriers.
To discuss the design principles for overcoming intracellular delivery barriers.
To explore therapeutic applications and clinical translation challenges of light-mediated gene delivery.

Main Methods:

Focus on light-triggered carriers as an alternative to viral and chemical delivery methods.
Analysis of carrier design strategies to enhance intracellular delivery efficiency.
Review of current and potential therapeutic applications of light-mediated gene therapy.

Main Results:

Light-mediated strategies show promise due to biocompatibility and improved intracellular delivery efficiency.
Specific design considerations can overcome intracellular barriers for nucleic acid delivery.
Various therapeutic applications are being explored, demonstrating the technology's potential.

Conclusions:

Light-triggered nucleic acid delivery carriers represent a significant advancement in gene therapy.
These systems offer a safer and more efficient alternative to conventional delivery methods.
Further research and development are needed to address challenges for successful clinical translation.