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Mean Platelet Volume to Platelet Distribution Width Ratio: The Most Effective Platelet Parameter in the Closer of
1Division of Neonatology, Department of Pediatrics, Health Sciences University, Ankara Bilkent City Hospital, Ankara - Turquia.
Insights
Platelet indices, particularly the mean platelet volume/platelet distribution width ratio, can help predict patent ductus arteriosus (PDA) in premature infants. Lower values of several platelet parameters were associated with hemodynamically significant PDA.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatric Cardiology
Background:
- The role of platelets in ductus arteriosus closure in preterm infants remains unclear.
- This study investigates platelet count and indices for predicting patent ductus arteriosus (PDA).
Purpose of the Study:
- To determine if platelet count and indices effectively predict the closure of PDA in premature infants.
- To compare demographic characteristics, prematurity morbidities, and platelet indices between infants with and without hemodynamically significant PDA (hsPDA).
Main Methods:
- Retrospective analysis of premature infants with gestational age <30 weeks.
- Platelet-related data collected from complete blood counts within the first 24 hours.
- Statistical analysis performed to identify significant predictors of hsPDA.
Main Results:
- 1151 infants included: 426 with hsPDA, 725 without.
- Significantly lower mean platelet volume (MPV), MPV/plateletcrit (PCT), MPV/platelet distribution width (PDW), platelet mass (PM), and red cell distribution width (RDW) in the hsPDA group.
- The MPV/PDW ratio showed the highest area under the curve (0.748) for PDA prediction.
Conclusions:
- The MPV/PDW ratio is the most valuable platelet index for predicting hsPDA.
- Platelet indices offer potential as biomarkers for PDA in preterm neonates.
Background:
The role of platelets and platelet indices in the closure of the ductus arteriosus in premature infants is still controversial. We aimed to determine whether the platelet count and all platelet-related indices are effective on the closer of patent ductus arteriosus (PDA).
Objectives:
Demographic characteristics, prematurity morbidities, and platelet indices were compared between groups with and without hemodynamically significant PDA (hsPDA).
Methods:
Data of premature infants with a gestational age of <30 weeks were evaluated retrospectively. All platelet-related data were recorded from the complete blood count in the first 24 hours of all patients. The statistical analysis was performed on the obtained data. A p-value of <0.05 was considered statistically significant.
Results:
A total of 1151 patients were included in the study, including 426 patients in the hsPDA group and 725 patients in the non-hsPDA group. Platelet parameters mean platelet volume (MPV), MPV/ plateletcrit (PCT), MPV/ platelet distribution width (PDW), platelet mass (PM), red cell distribution width (RDW) values were found to be significantly lower in the hsPDA group compared to the non-hsPDA group (p<0.001, p<0.001, p<0.001, p=0.015, and p<0.001, respectively). MPV/PDW ratio with the highest AUC value (0.748) was found to be the most valuable parameter in estimating the closer of PDA.
Conclusions:
The MPV/PDW ratio was found to be the most valuable parameter for the prediction of hsPDA among all platelet indices.
