ESR1 overexpression is a biomarker of relapse and worse prognosis in stage I endometrioid endometrial carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Estrogen receptor 1 (ESR1) gene overexpression predicts relapse risk in early-stage endometrioid endometrial carcinoma (EEC). This finding offers a new biomarker for identifying high-risk patients who may benefit from closer monitoring or targeted therapies.
Area Of Science
- Gynecologic Oncology
- Molecular Biology
- Cancer Genomics
Background
- Endometrial cancer (EC), particularly endometrioid endometrial carcinoma (EEC), is a common malignancy.
- Early-stage EEC often has a good prognosis, but some patients experience relapse without clear predictive markers.
- A reliable biomarker for predicting relapse in stage I EEC is currently lacking.
Purpose Of The Study
- To identify differentially expressed genes in stage I EEC using transcriptome analysis.
- To discover a predictive biomarker for tumor relapse in stage I EEC patients.
- To validate the prognostic significance of identified genes in an independent cohort.
Main Methods
- Transcriptome analysis of stage I EEC tumors comparing relapsed and non-relapsed cases.
- Validation of ESR1 gene overexpression in an independent cohort of 64 stage I EEC samples.
- Assessment of estrogen receptor alpha (ERα) protein levels in relation to relapse.
Main Results
- The estrogen receptor 1 (ESR1) gene was significantly overexpressed (4.3-fold) in relapsed stage I EEC tumors compared to non-relapsed tumors.
- ESR1 overexpression was validated in an independent cohort and identified as an independent prognostic variable for disease-free survival (HR=7.25) and overall survival (HR=5.15).
- Estrogen receptor alpha (ERα) protein levels did not differ significantly between relapsed and non-relapsed tumors.
Conclusions
- ESR1 gene overexpression serves as a potential biomarker for predicting poor prognosis and relapse in stage I EEC.
- This finding may aid in identifying high-risk patients who require intensified surveillance or treatment strategies.
- Further research is warranted to explore the therapeutic implications of ESR1 targeting in EEC.
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