Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetic neuropathy.

P J Dyck, A Windebank, H Yasuda

    Advances in Experimental Medicine and Biology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Activity measurements of the radionuclides <sup>18</sup>F and <sup>64</sup>Cu for the NIST, USA in the ongoing comparisons BIPM.RI(II)-K4.F-18 and BIPM.RI(II)-K4.Cu-64.

    Metrologia·2020
    Same author

    Determination of the half-life and the absolute photon emission intensities for the main gamma-ray energies of <sup>124</sup>I.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2020
    Same author

    Pathology of Oropharyngeal Fibropapillomatosis in Green Turtles Chelonia mydas.

    Journal of aquatic animal health·2017
    Same author

    Determination of photon emission probability for the main gamma ray and half-life measurements of <sup>64</sup>Cu.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2017
    Same author

    SU-E-I-45: Measurement of CT Dose to An HDPE Phantom Using Calorimetry: A Feasibility Study.

    Medical physics·2017
    Same author

    Pathology of Oropharyngeal Fibropapillomatosis in Green Turtles Chelonia mydas.

    Journal of aquatic animal health·2015
    Same journal

    Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

    Advances in experimental medicine and biology·2026
    Same journal

    Methods for the Investigation of Protein-Ligands Interactions.

    Advances in experimental medicine and biology·2026
    Same journal

    Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

    Advances in experimental medicine and biology·2026
    Same journal

    Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

    Advances in experimental medicine and biology·2026
    Same journal

    Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

    Advances in experimental medicine and biology·2026
    Same journal

    Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

    Advances in experimental medicine and biology·2026
    See all related articles

    Diabetic neuropathies are common in both types of diabetes, but their exact occurrence is unknown. Research suggests altered nerve microenvironments, not just high blood sugar, may cause nerve damage.

    Area of Science:

    • Neurology
    • Endocrinology
    • Epidemiology

    Background:

    • Diabetic neuropathies are common complications of both Insulin Dependent Diabetes Mellitus (IDDM) and Non-Insulin Dependent Diabetes Mellitus (NIDDM).
    • Previous studies lacked standardized methods, population-based data, and prospective designs, hindering accurate incidence and prevalence determination.
    • The direct or indirect effects of hyperglycemia on neural tissue remain unclear.

    Purpose of the Study:

    • To establish accurate incidence and prevalence rates for diabetic neuropathies.
    • To investigate the causal mechanisms linking hyperglycemia to neural dysfunction.
    • To explore the role of the nerve microenvironment in diabetic neuropathy development.

    Main Methods:

    • Initiated prospective, population-based epidemiologic studies.

    Related Experiment Videos

  • Employed a uniform algorithm for classifying diabetic disorders.
  • Utilized validated approaches for assessing neuropathic symptoms, deficits, and quantitative neural dysfunction endpoints.
  • Examined nerve oxygen tension and blood flow in streptozotocin-induced diabetes models.

    • Main Results:

    • Established standardized methods for diagnosing and monitoring diabetic neuropathy.
    • Observed that improved hyperglycemia control did not correlate with rapid neurologic improvement, suggesting intervening tissue alterations.
    • Found decreased nerve oxygen tension and blood flow in diabetic models, indicating microenvironmental changes.

    Conclusions:

    • Accurate incidence and prevalence of diabetic neuropathies require standardized, prospective, population-based studies.
    • Intervening tissue alterations, potentially in the nerve microenvironment, may play a significant role in diabetic neuropathy pathogenesis.
    • Further research is needed to elucidate the precise mechanisms linking metabolic changes to neural damage in diabetes.