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The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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Sinonasal angiofibroma in a horse.

Magdalena Schollmeyer1, Elisabeth M Liebler-Tenorio2, Christina Felton3

  • 1Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 33, 04103, Leipzig, Germany.

Journal of Comparative Pathology
|May 14, 2025
PubMed
Summary

A Haflinger gelding developed a large intranasal mass diagnosed as an angiofibroma. This rare equine tumor, similar to canine and human cases, required euthanasia due to its aggressive nature.

Keywords:
histopathologyhorseimmunohistochemistrynasal tumourneoplasia

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Area of Science:

  • Equine Medicine
  • Veterinary Pathology
  • Oncology

Background:

  • Intranasal masses in horses can present diagnostic challenges.
  • Recurrence after incomplete excision necessitates further investigation.

Purpose of the Study:

  • To diagnose and characterize a rare intranasal mass in a Haflinger gelding.
  • To compare findings with similar neoplasms in other species.

Main Methods:

  • Clinical examination, radiography, and macroscopic evaluation.
  • Histopathological analysis with immunohistochemistry (alpha-smooth muscle actin, vimentin, factor VIII-related antigen).

Main Results:

  • A large, pedunculated, expansile intranasal mass was identified originating from the maxillary sinus.
  • Histopathology revealed a well-vascularized neoplasm consistent with angiofibroma.
  • Immunohistochemistry supported the diagnosis by identifying specific cellular markers.

Conclusions:

  • The intranasal mass was diagnosed as an angiofibroma, a rare tumor in horses.
  • The tumor exhibited aggressive growth and similarities to canine and human angiofibromas.
  • Complete surgical excision may be challenging due to the tumor's origin and vascularity.