Two sesquiterpenoids and a steroid produced by an endophytic fungus Aspergillus sp. YUD20004 and their bioactivity
Dan-Dan Xia1, Jing-Xin Chen2, Fei Xie1
1Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; Institute of International Rivers and Eco-security, Yunnan University, Kunming 650500, China.
Abstract:
Two new sesquiterpenoids asperpenoids A-B (1-2) and one new ergostane-type steroid aspergteroid (3) were isolated from the fungus Aspergillus sp. YUD20004 which was derived from the tuber of Zingiber officinale Roscoe. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, electronic circular dichroism (ECD) spectra and consideration of the biogenetic origins. Especially, asperpenoid A was featured as a rare spiro[6-oxabicyclo[3.2.1]octane-2,2'-oxirane] 5/6/3 tricyclic skeleton. In vitro cytotoxic activity assays, aspergteroid (3) exhibited significant cytotoxic activities against five human cancer cell lines (SMMC-7721, HL-60, A549, SW480 and MDA-MB-231) with IC50 values ranging from 0.40 to 34.24 μM. Most significantly, compound 3 reduced the viability of SMMC-7721 cells in a concentration-dependent manner with an IC50 value of 0.40 μM.
Related Concept Videos
Bacterial Phylum Actinobacteria
Fungal Group Zygomycota
Fungal Phylum Ascomycota
Probiotics
Production of Organic Acids
Production of Antibiotics


