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Updated: May 3, 2026

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
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Long-circulating enzyme-activated HSP90-targeted camptothecin derivatives

Mengyuan Ding1, Qianqian Shen2, Yi Su2

  • 1Innovation Center for AI and Drug Discovery, School of Pharmacy, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 14, 2025
PubMed
Summary

Researchers developed novel albumin-binding prodrugs for enhanced camptothecin delivery. These drug delivery systems improve tumor targeting and anti-cancer efficacy while reducing side effects, offering a promising approach for cancer therapy.

Keywords:
Camptothecin derivativesCathepsin BLong-circulatingeHSP90

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