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Updated: Jun 16, 2025

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
Published on: November 12, 2019
Using TCR-CAR dual signaling for precise cancer targeting
Mohammad Shahbazy1, Isabelle Rose Leo2, Pouya Faridi3
1Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
None:
Recently, Kondo et al. engineered the coexpression of a T cell receptor (TCR) and a chimeric antigen receptor (CAR) and developed an antagonism-enforced braking system where TCR signals both enhance and inhibit CAR activation. This work may enable rational design of CAR-T agents that limit toxicity to healthy tissue.
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