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An Autopsied Case of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

Yusuke Sonezaki¹, Wataru Shiraishi², Izumi Kinoshita³

¹Department of Nephrology, Kokura Memorial Hospital, Japan.

Internal Medicine (Tokyo, Japan)

|May 14, 2025

Abstract:

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare inflammatory disease of the central nervous system, and many details, including pathological findings, are still unclear. We herein report a man in his 70s who had been diagnosed with CLIPPERS 4.5 years ago. He was treated with corticosteroids, and his symptoms were managed; however, he eventually died of coronavirus disease 2019. A postmortem autopsy revealed perivascular lymphocyte aggregation and demyelination centered in the brainstem and cerebellum. This is the world's first autopsied case of CLIPPERS with more than four years of follow-up.

Keywords:

CD3+ cells CLIPPERS demyelination lymphocytes lymphoma pathology

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