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STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity

Jiajia Zhou1,2, Kole Tison1,2,3,4, Haibin Zhou5

  • 1Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.

Nature
|May 14, 2025
PubMed
Summary

Immune checkpoint blockade (ICB) efficacy relies on dendritic cells. New research reveals STAT3 and STAT5 pathway interplay in dendritic cells is key for ICB success, with STAT3 degraders showing promise in cancer therapy.

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