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Updated: Aug 17, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
Acalculous cholecystitis in the neonate
Insights
Neonatal acalculous cholecystitis, a rare gallbladder inflammation without stones, presents uniquely in newborns. Early diagnosis via imaging and surgical removal (cholecystectomy) are crucial for management.
Area of Science:
- Pediatric Surgery
- Neonatal Medicine
- Gastroenterology
Background:
- Pediatric acalculous cholecystitis is uncommon, with neonatal cases being exceptionally rare.
- Nonlithogenic biliary disease in neonates is poorly documented, with only isolated case reports.
- Neonatal inflammatory gallbladder disease often co-occurs with systemic illness.
Abstract:
Pediatric acalculous cholecystitis is a well-described though uncommon affliction. However, during the neonatal period nonlithogenic biliary disease is extremely unusual and only isolated reports of this problem exist. Nine previously reported cases are reviewed, and an additional case of a 6-day-old female neonate with a right-upper-quadrant mass is presented in detail. Inflammatory gallbladder disease in the neonate is often associated with concurrent systemic illness. An abdominal mass is palpable in almost all cases. Diagnosis may be confirmed in these patients by radionuclide scanning and ultrasonography. The treatment is cholecystectomy.
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