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Sorbitol intolerance in adults.

N K Jain, D B Rosenberg, M J Ulahannan

    The American Journal of Gastroenterology
    |September 1, 1985
    PubMed
    Summary
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    Many adults experience sorbitol intolerance, leading to abdominal discomfort and diarrhea. This study found significant sorbitol intolerance in adults, particularly nonwhites, highlighting a common cause of digestive issues.

    Area of Science:

    • Gastroenterology
    • Human Nutrition

    Background:

    • Sorbitol is a common sugar substitute in sugar-free products.
    • Sorbitol intolerance is known in children but less documented in adults.

    Purpose of the Study:

    • To investigate the prevalence and severity of sorbitol intolerance in healthy adults.
    • To correlate clinical symptoms with breath hydrogen concentration.

    Main Methods:

    • 42 healthy adults ingested 10g of sorbitol solution.
    • End-expiratory breath samples were collected for 4 hours to measure H2 concentration.
    • Clinical symptoms of sorbitol intolerance were recorded.

    Main Results:

    • 43% of whites and 55% of nonwhites showed clinical sorbitol intolerance.

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  • Severe intolerance was significantly higher in nonwhites (32%) vs. whites (4%).
  • A strong correlation existed between symptom severity and exhaled hydrogen levels.

    • Conclusions:

    • A significant number of adults may suffer from undiagnosed sorbitol intolerance.
    • Sorbitol intolerance can cause nonspecific abdominal symptoms and diarrhea, potentially leading to misdiagnosis of IBS.
    • Awareness of sorbitol intolerance is crucial for adults, especially those consuming sugar-free or dietetic foods.