Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic lupus erythematosus and reproductive function: a case-control study.

D A Grimes, S A LeBolt, K R Grimes

    American Journal of Obstetrics and Gynecology
    |September 15, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    'Allocation concealment': the evolution and adoption of a methodological term.

    Journal of the Royal Society of Medicine·2018
    Same author

    Immediate start of hormonal contraceptives for contraception.

    The Cochrane database of systematic reviews·2008
    Same author

    Strategies for communicating contraceptive effectiveness.

    The Cochrane database of systematic reviews·2008
    Same author

    Skin patch and vaginal ring versus combined oral contraceptives for contraception.

    The Cochrane database of systematic reviews·2008
    Same author

    LRRK2 screening in a Canadian Parkinson's disease cohort.

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2007
    Same author

    Steroid hormones for contraception in men.

    The Cochrane database of systematic reviews·2007
    Same journal

    Likelihood ratios enhance clinical interpretation of metagenomic prediction of early-onset neonatal sepsis in preterm premature rupture of membranes (Letter-to-the-Editor).

    American journal of obstetrics and gynecology·2026
    Same journal

    Taking risk stratification in preterm premature rupture of membranes to the bedside (Reply to Letter-to-the-Editor).

    American journal of obstetrics and gynecology·2026
    Same journal

    Gestational Age at Full-Term Delivery and Long-Term Offspring Morbidity in Low-Risk Pregnancies: A Population-Based Cohort Study.

    American journal of obstetrics and gynecology·2026
    Same journal

    Trajectories of childbirth-related posttraumatic stress symptoms after a vaginal delivery: a multicenter prospective study.

    American journal of obstetrics and gynecology·2026
    Same journal

    Early life adversity and polycystic ovary syndrome among North American pregnancy planners.

    American journal of obstetrics and gynecology·2026
    Same journal

    Survival assessment of adjuvant chemotherapy for cytology-negative, non-myoinvasive stage IC clear cell endometrial cancer.

    American journal of obstetrics and gynecology·2026
    See all related articles

    Younger women and minority women face higher systemic lupus erythematosus (SLE) risks. Procedures like hysterectomy may offer protection, suggesting retrograde menstruation could be an SLE trigger.

    Area of Science:

    • Immunology
    • Reproductive Health
    • Epidemiology

    Background:

    • Systemic lupus erythematosus (SLE) predominantly affects women of reproductive age.
    • The underlying reasons for this demographic prevalence remain unclear.
    • Reproductive factors are hypothesized to influence SLE risk.

    Purpose of the Study:

    • To investigate reproductive and demographic risk factors for systemic lupus erythematosus (SLE).
    • To explore the potential role of retrograde menstruation in SLE pathogenesis.

    Main Methods:

    • A hospital-based, case-control study design.
    • Inclusion of 109 incident cases of SLE and 109 matched controls.
    • Analysis of reproductive history, age, race, and gynecological conditions.

    Related Experiment Videos

    Main Results:

    • Younger women (≤34 years) exhibited a 3.6-fold increased risk of SLE.
    • Minority women showed a 4.8-fold higher risk compared to white women (P < 0.001).
    • Prior hysterectomy or tubal sterilization demonstrated a protective effect (OR=0.55).
    • Endometriosis was linked to a non-significant twofold increase in SLE risk.

    Conclusions:

    • Reproductive factors, particularly age and race, are significantly associated with SLE risk.
    • Surgical interventions affecting the reproductive tract appear protective against SLE.
    • Findings support the hypothesis that retrograde menstruation may contribute to SLE development in susceptible individuals.