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Heterotypic Droplet Formation by Pro-Inflammatory S100A9 and Neurodegenerative Disease-Related α-Synuclein

Dominykas Veiveris1, Aurimas Kopustas1,2, Darius Sulskis1

  • 1Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius LT-10257, Lithuania.

Biomacromolecules
|May 15, 2025
PubMed
Summary

Pro-inflammatory S100A9 protein forms liquid-liquid phase separation (LLPS) droplets with alpha-synuclein. This interaction alters alpha-synuclein aggregation, offering insights into neurodegenerative disease mechanisms.

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