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Updated: May 16, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Modifications of terpenoids via inert aliphatic C-H bond heteroarylation with heteroarenes
Shuxin Yang1, Huirong Li1, Jiaxing Lv1
1School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China. beeyee_413@163.com.
Abstract:
Here, we describe a method to modify commercially abundant terpenoids via inert aliphatic C-H bond heteroarylation directly with heteroarenes. The reaction is catalyzed by decatungstate anion under near-ultraviolet light irradiation. Furthermore, the inhibition effect of lipopolysaccharide (LPS)-induced nitric oxide (NO) production activity and cell proliferative inhibition in HUVEC and HCC1806 cells of the derivatives were evaluated. The heteroarylation could significantly result in changes in biological activity of terpenoids.
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