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Related Experiment Video

Updated: Jun 28, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Innovative cage-based technique for mouse urine collection.

Jianhua Huang1, Yan Wang1, Yan Gao2

  • 1Department of Clinical Services, Merck & Co., Inc., Rahway, USA.

Laboratory Animals
|May 15, 2025
PubMed
Summary
This summary is machine-generated.

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A new, non-invasive mouse urine collection device minimizes stress and contamination. This animal-friendly method yields high-quality samples for research and health monitoring, improving laboratory animal welfare.

Area of Science:

  • Laboratory animal science
  • Biomedical research methodology
  • Animal welfare science

Background:

  • Conventional mouse urine collection methods can cause animal stress and compromise sample integrity.
  • There is a need for humane and accurate techniques for collecting mouse urine samples in research settings.

Purpose of the Study:

  • To develop and evaluate a novel, non-invasive, and animal-friendly method for collecting mouse urine samples.
  • To assess the quality and quantity of urine samples obtained using the new technique.

Main Methods:

  • A specially designed urine collection device with individual transparent compartments and 96-well plates was utilized.
  • C57BL/6NTac mice were allowed to urinate freely for up to 2 hours in the device.
  • Urine collection was optimized during the 7 AM to 9 AM period.
Keywords:
3RsMousealternativeslaboratory animal welfarequality assurance/controlurine collection

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Last Updated: Jun 28, 2026

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Main Results:

  • The optimized collection period (7 AM - 9 AM) yielded urine volumes between 80 μl and 810 μl.
  • 85% of mice produced over 150 μl of urine, indicating sufficient sample volume.
  • The 96-well plate system effectively minimized animal stress, sample evaporation, and fecal contamination.

Conclusions:

  • The developed cage-based, non-invasive technique provides a user-friendly solution for obtaining accurate, high-quality mouse urine samples.
  • This method enhances animal welfare and facilitates reliable rodent health surveillance and research.
  • The innovative device supports improved data accuracy in studies relying on mouse urine analysis.