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Ubiquitination in lipid metabolism reprogramming: implications for pediatric solid tumors
Weixin Zhang1, Yile Xu1, Yingjin Fang2,3,4
1Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, Guangdong, China.
Frontiers in Immunology
|May 15, 2025
Summary
Ubiquitination regulates lipid metabolism in pediatric solid tumors, impacting cancer growth and treatment resistance. Targeting the ubiquitin-proteasome system offers new therapeutic strategies for childhood cancers.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Pediatric solid tumors are a major cause of childhood cancer, with survival disparities based on economic setting.
- Lipid metabolic reprogramming is a key cancer hallmark, influencing tumor progression, resistance, and immune evasion.
- The ubiquitin-proteasome system (UPS) regulates lipid metabolism by controlling key enzymes and transporters.
Purpose of the Study:
- To review the role of ubiquitination in lipid metabolic reprogramming within pediatric solid tumors.
- To explore how ubiquitination influences cholesterol and fatty acid pathways in these cancers.
- To identify potential UPS-mediated therapeutic targets for improved pediatric cancer treatment.
Main Methods:
- Comprehensive literature review of studies on ubiquitination, lipid metabolism, and pediatric solid tumors.
- Analysis of mechanisms linking ubiquitination to cholesterol and fatty acid pathways.
- Identification and evaluation of potential therapeutic targets within the UPS.
Main Results:
- Ubiquitination significantly impacts cholesterol biosynthesis, uptake, efflux, and fatty acid metabolism in pediatric solid tumors.
- Dysregulated lipid metabolism, influenced by ubiquitination, promotes tumor growth and survival.
- Specific UPS components and targets involved in lipid metabolism have been identified as potential therapeutic avenues.
Conclusions:
- Targeting the UPS to disrupt lipid metabolism presents a promising strategy for pediatric solid tumors.
- Integrating ubiquitination-based therapies could enhance efficacy and overcome treatment resistance.
- This review provides a foundation for developing novel, precision medicine approaches for childhood cancers.
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