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LncRNA MALAT1 serves as a risk factor in perioperative respiratory adverse events in children under general

Yuan Gao1, Bo Wang2, Shuai Wang3

  • 1Department of Anesthesiology, Jingzhou Hospital Affiliated to Yangtze University, No. 4, Renmin Road, Jingzhou District, Jingzhou 434020, Hubei Province, China.

Toxicology Research
|May 15, 2025
PubMed

Insights

Elevated long non-coding RNA MALAT1 levels in children undergoing general anesthesia may predict perioperative respiratory adverse events (PRAE). This finding aids in assessing anesthesia risks and improving patient outcomes.

Area of Science:

  • Anesthesiology
  • Molecular Biology
  • Pediatric Medicine

Background:

  • Perioperative respiratory adverse events (PRAE) are common in pediatric anesthesia.
  • Accurate preoperative risk assessment is crucial for mitigating surgical risks.

Purpose of the Study:

  • To investigate the expression level of long non-coding RNA MALAT1 in children experiencing PRAE.
  • To evaluate the predictive performance of MALAT1 for PRAE in pediatric general anesthesia.

Main Methods:

  • Retrospective analysis of 236 pediatric patient records, divided into PRAE and No-PRAE groups.
  • Quantification of serum MALAT1 levels using qRT-PCR.
  • Multivariate logistic regression and ROC curve analysis to assess risk factors and diagnostic performance.

Main Results:

  • Serum MALAT1 levels were significantly higher in the PRAE group compared to the No-PRAE group.
  • Higher MALAT1 levels, preoperative airway disease, and longer anesthesia duration were identified as risk factors for PRAE.
  • ROC analysis showed an area under the curve of 0.885, with 79.44% sensitivity and 82.17% specificity for MALAT1 in predicting PRAE.

Conclusions:

  • Increased serum MALAT1 is a potential indicator for predicting PRAE in children undergoing general anesthesia.
  • MALAT1 holds referable value as a risk factor for PRAE prediction.
  • This research contributes to improved risk stratification and management of pediatric anesthesia.

Keywords:
MALAT1general anesthesiaperioperative respiratory adverse events

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