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CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast

Yuncheng Bei1, Sijie Wang1, Rui Wang1

  • 1Clinical Stem Cell Center, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.

Acta Pharmaceutica Sinica. B
|May 15, 2025
PubMed

Keywords:
Breast cancerCDK5Drug resistanceGlucose-6-phosphoate dehydrogenaseIntracellular redox homeostasisIsotopomer spectral analysisOlaparibPentose phosphate pathway

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