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White matter functional connectome gradient dysfunction in major depressive disorder.

Baoxin Yu1,2,3, Xiaoyi Sun1,2,3,4, Mingrui Xia1,2,3

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Summary
This summary is machine-generated.

Major depressive disorder (MDD) involves altered brain white matter (WM) functional organization. This study reveals a contracted WM hierarchy in MDD patients, linked to symptom severity.

Keywords:
brain networkdepressionfMRIfunctional connectivityhierarchywhite matter functional network

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Major depressive disorder (MDD) is a common psychiatric condition.
  • Disruptions in brain white matter (WM) are observed in MDD.
  • The precise organization of WM in MDD is not well understood.

Purpose of the Study:

  • To investigate white matter (WM) functional connectome gradients in major depressive disorder (MDD).
  • To identify global and regional alterations in WM organization in MDD patients.
  • To explore the relationship between WM gradient properties and depressive symptom severity.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (rs-fMRI) data.
  • Analyzed data from 48 MDD patients and 68 healthy controls (HC).
  • Characterized WM functional connectome gradients and performed external validation.

Main Results:

  • MDD patients exhibited a contracted WM hierarchy with reduced gradient range and spatial variation compared to HC.
  • Specific WM tracts, including the uncinate fasciculus (UF) and anterior thalamic radiation (ATR), showed altered gradient scores in MDD.
  • WM tract gradient patterns accounted for 37.2% of the variance in clinical severity.

Conclusions:

  • Altered WM functional connectome gradients are a feature of MDD.
  • These alterations are associated with the severity of depressive symptoms.
  • Findings offer insights into MDD neurobiology and potential biomarkers for symptom assessment.