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Updated: May 17, 2025

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
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Species Differences of P2X4 Receptor Modulators

Jessica Nagel1, Christiane Bous1, Aliaa Abdelrahman1

  • 1PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

ACS Pharmacology & Translational Science
|May 15, 2025
PubMed
Summary

This study compares P2X4 receptors across nine species, finding significant potency differences for agonists and antagonists. These findings are crucial for selecting appropriate animal models in drug development for conditions like neuropathic pain.

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