PEG-based polyurethane bioadhesive for wet and adaptable adhesion to circumcision wounds

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Surgical Innovation

Background:

• Effective wound management is crucial for post-operative recovery, especially after circumcision.
• Current methods may face challenges in maintaining adhesion and promoting healing on moist tissue surfaces.

Purpose of the Study:

• To design and evaluate a novel two-component polyurethane (PU) bioadhesive, PU1000S, for advanced wound care in circumcision.
• To assess its adhesion properties, durability, and impact on wound healing.

Main Methods:

• Development of a PU bioadhesive (PU1000S) engineered for rapid water absorption and curing on wet tissues.
• Evaluation of lap-shear strength, durability, and mechanical adaptability under complex loading conditions.
• Assessment of wound healing parameters including re-epithelialization and collagen deposition post-application.

Main Results:

• PU1000S demonstrated rapid curing (160s) and strong wet adhesion with a lap-shear strength of 55.12 ± 6.88 kPa.
• The bioadhesive maintained stability under complex mechanical stresses, showing minimal debonding on wet skin.
• PU1000S significantly accelerated wound healing, promoting re-epithelialization and collagen deposition.

Conclusions:

• PU1000S exhibits superior wet adhesion, durability, and bioadaptability for circumcision wound closure.
• This novel bioadhesive shows promise for enhancing clinical outcomes and patient satisfaction in advanced wound care.