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Zebrafish and bioactive compounds: a bibliometric review.

João Paulo Lima de Oliveira1, Kiara Cândido Duarte da Silva2, Bianca Aparecida de Sousa3

  • 1Lavras School of Agricultural Sciences, Department of Agriculture, Federal University of Lavras, Lavras, Minas Gerais 37200-900 Brazil.

In Silico Pharmacology
|May 15, 2025
PubMed
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This bibliometric study analyzed research on zebrafish and bioactive compounds. Publications increased significantly from 2018, highlighting medicinal plants in drug development.

Area of Science:

  • Pharmacology and Toxicology
  • Biochemistry
  • Genetics

Background:

  • Zebrafish models are increasingly used for oxidative stress research.
  • Medicinal plants offer bioactive compounds with antioxidant properties, crucial for this research.
  • Bibliometrics provides a framework for analyzing research output and trends.

Purpose of the Study:

  • To conduct a bibliometric review of publications on "zebrafish" and "bioactive compounds."
  • To analyze the evolution and trends of research at the intersection of these two fields.
  • To identify key authors, countries, journals, and research themes.

Main Methods:

  • Bibliometric analysis of publications from the Web of Science (WoS) database (2004-2024).
  • Utilized VOSviewer software for analyzing authors, countries, journals, co-authorship, keyword co-occurrence, and co-citation.
Keywords:
Danio RerioNatural productsPlantsSecondary metabolites

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  • Retrieved and analyzed 170 documents.

    • Main Results:

    • The highest number of publications was observed in 2022.
    • Jean Luc Wolfender, the United States, and PLoS One were prominent in citations.
    • Key keywords included "zebrafish," "bioactive compounds," "angiogenesis," "antioxidant," and "oxidative stress."

    Conclusions:

    • Research on zebrafish and bioactive compounds has surged since 2018.
    • The Pharmacy/Pharmacology field shows strong emphasis on developing new drugs from medicinal plants.
    • This trend underscores the therapeutic potential of plant-derived bioactive compounds.