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Related Experiment Videos

A human sperm coating antigen isolated from sperm cell membrane.

F Saji, Y Minagawa, T Negoro

    American Journal of Reproductive Immunology and Microbiology : AJRIM
    |August 1, 1985
    PubMed
    Summary

    Researchers identified a unique human sperm antigen, a glycoprotein found in sperm and seminal plasma. This antigen, also present in milk, is highly concentrated in seminal plasma, suggesting a role as a sperm-coating seminal plasma antigen.

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    Area of Science:

    • Reproductive biology
    • Immunology
    • Biochemistry

    Background:

    • Sperm and seminal plasma contain specific antigens crucial for reproductive processes.
    • Understanding these antigens can aid in diagnostics and therapeutics.

    Purpose of the Study:

    • To isolate and characterize a novel human sperm cell membrane antigen.
    • To investigate the antigen's specificity and distribution in various biological fluids and tissues.

    Main Methods:

    • Isolation of a human sperm cell membrane antigen using rabbit antiserum against human seminal plasma.
    • Characterization of the antigen's properties, including molecular weight, lectin affinity, and tissue distribution.

    Main Results:

    • A glycoprotein antigen of approximately 12,000 daltons with lentil lectin affinity was isolated.

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  • The antigen demonstrated high specificity to sperm and seminal plasma, also found in human milk but not other tissues.
  • Seminal plasma contained the highest concentration of the antigen, significantly exceeding levels in spermatozoa and milk.

    • Conclusions:

    • The isolated antigen is a glycoprotein highly specific to human sperm and seminal plasma.
    • Its significant presence in seminal plasma suggests it may function as a sperm-coating seminal plasma antigen.
    • The antigen's unique distribution warrants further investigation into its biological roles.