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[Sleep disorders in imprinting disorders].

E M Ivannikova1, T Yu Degtyarevskaya1, N N Tarasova2

  • 1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|May 15, 2025
PubMed
Summary

Genomic imprinting disorders, including Angelman and Prader-Willi syndromes, are linked to specific gene expression issues causing sleep disturbances. Current treatments show promise for managing these complex sleep disorders.

Keywords:
Angelman syndromePrader—Willi syndromeimprinting disordersinsomniasleep apneasleep disorders

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Area of Science:

  • Genetics
  • Neuroscience
  • Sleep Medicine

Background:

  • Genomic imprinting disorders, such as Angelman syndrome and Prader-Willi syndrome, are complex genetic conditions.
  • These syndromes are characterized by specific genetic and epigenetic alterations affecting gene expression.
  • Sleep disturbances are a common and significant clinical feature in individuals with these disorders.

Purpose of the Study:

  • To review the current understanding of the etiology and pathogenesis of genomic imprinting disorders.
  • To detail the mechanisms linking impaired gene expression to sleep disorders in Angelman and Prader-Willi syndromes.
  • To evaluate modern treatment strategies for sleep disorders in these patient populations.

Main Methods:

  • Literature review of peer-reviewed scientific articles.
  • Analysis of genetic and epigenetic factors contributing to genomic imprinting disorders.
  • Synthesis of research on sleep disorder mechanisms and treatment efficacy.

Main Results:

  • Impaired expression of specific imprinted genes is a key factor in the pathogenesis of sleep disorders in these syndromes.
  • Various genetic and epigenetic mechanisms underlie the observed sleep abnormalities.
  • Current treatment modalities demonstrate effectiveness and potential for clinical application.

Conclusions:

  • Understanding the genetic basis of sleep disorders in Angelman and Prader-Willi syndromes is crucial for effective management.
  • Targeted therapies addressing gene expression may offer novel treatment avenues.
  • Further research into the long-term efficacy and broader applicability of current treatments is warranted.