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A Self-Circulated Microenvironment-Adaptive Nanozyme for Wound Healing Acceleration.

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Researchers developed a novel nanozyme that regenerates its active site, enabling continuous reactive oxygen species (ROS) control for effective infected wound healing and bacterial eradication.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Wound Healing

Background:

  • Nanozyme-based reactive oxygen species (ROS) homeostasis is crucial for infected wound healing.
  • Nanozyme inactivation due to active center loss hinders sustained therapeutic effects.
  • Achieving a balance between ROS production and scavenging in vivo remains challenging.

Purpose of the Study:

  • To design a nanozyme with a regenerated active center for sustained therapeutic activity.
  • To develop a nanozyme capable of controllable and reversible ROS generation and scavenging.
  • To enhance infected wound healing through nanozyme-mediated ROS regulation and oxygen release.

Main Methods:

  • Preparation of a novel nanozyme with a regenerated Fe(II) active center by adjusting ligands and metal charge transfer.
  • Demonstration of cyclic and continuous oxidoreductase activities (peroxidase, superoxide dismutase, catalase, oxidase) at neutral pH.
  • Evaluation of the nanozyme's effectiveness in controlling ROS, releasing oxygen, and eradicating bacteria in infected wounds.

Main Results:

  • The developed nanozyme exhibits versatile enzymatic activity with a regenerated Fe(II) active center.
  • Controllable and reversible ROS generation/scavenging and oxygen release were achieved.
  • Ultralow dosage of the nanozyme demonstrated significant effectiveness against drug-resistant bacteria and accelerated wound healing (approx. 6.3 mm²/day).

Conclusions:

  • The novel nanozyme design overcomes active center inactivation, providing sustained therapeutic benefits.
  • This approach offers a promising strategy for advanced nanozyme-based infected wound management.
  • The regenerated active center nanozyme represents a key breakthrough in wound healing applications.