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Selective Serotonin Reuptake Inhibitors (SSRIs): Effects on male fertility
Raisa Arruda de Oliveira1, Suellen Casado Dos Santos2, Vera Lúcia de Menezes Lima2
1Embriológica, Pós-graduação, São Paulo, Brazil.
JBRA Assisted Reproduction
|May 15, 2025
Summary
Selective Serotonin Reuptake Inhibitors (SSRIs) may negatively impact male fertility, affecting sperm production and testosterone levels. Further research is needed to confirm these effects and understand their causes.
Area of Science:
- Reproductive Endocrinology
- Pharmacology
Background:
- Selective Serotonin Reuptake Inhibitors (SSRIs) are widely prescribed for depression.
- Potential impacts of SSRIs on male reproductive health are a growing concern.
Purpose of the Study:
- To systematically review the literature on the adverse effects of SSRIs on male fertility.
- To analyze the impact of SSRIs on semen parameters and sperm function.
Main Methods:
- Systematic literature review using PRISMA guidelines.
- Search conducted using keywords related to SSRIs and male fertility.
- Analysis of 10 selected articles from an initial pool of 125 studies.
Main Results:
- SSRIs were associated with decreased serum testosterone levels.
- Reduced sperm production and decreased sperm reserves in the epididymis were observed.
- Increased sperm transit time in the epididymis was noted.
Conclusions:
- SSRIs may adversely affect male fertility.
- Further randomized clinical trials are necessary to elucidate the mechanisms of SSRI-induced spermatogenic failure.
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