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Electrophilic (Hetero)Arene C-H Nitration by Ferric Nitrate Nonahydrate in Hexafluoroisopropanol
Yuzhu Zheng1, Zongyi Liu1, Zhaobo Ying1
1Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education; Hubei Key Laboratory of Materials Chemistry and Service Failure; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China.
Abstract:
In this article, we provide an extended substrate scope and more detailed mechanistic studies of an operationally simple and generally applicable arene nitration that we previously reported. This method utilizes safe and inexpensive Fe(NO3)3•9H2O as the nitro source in easily recyclable HFIP and obviates the need for corrosive acids (HNO3 + H2SO4). As a result, we speculated that it could serve as an effective substitute for the traditional mixed acid approach under most scenarios due to its operational simplicity. A general guidance for the application of this method was provided.
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