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Published on: December 10, 2020
Contemporary Strategies for Mesenteric Malperfusion in Acute Aortic Dissection
Ivan B Ye1, Matteo D'Arduini, Neal S Cayne
1From the Division of Vascular Surgery, NYU Langone Hospital-Long Island, Mineola, NY.
Abstract:
Mesenteric malperfusion is a rare complication of aortic dissection associated with high mortality. Diagnosis requires a high degree of suspicion as treatment is time-sensitive, necessitating early revascularization to prevent bowel necrosis, sepsis, and multi-organ failure. Advances in endovascular techniques have improved outcomes and survival over traditional approaches. Management of type A aortic dissection with mesenteric malperfusion has shifted from central aortic repair first to a two-stage approach with revascularization and delayed aortic repair. Thoracic endovascular aortic repair has become the standard treatment for type B aortic dissection with mesenteric malperfusion. However, finding the balance between aortic repair and treating mesenteric malperfusion remains a challenge. This review highlights current strategies and promising research into new endovascular techniques and refining treatment pathways.
Insights
Mesenteric malperfusion, a complication of aortic dissection, requires prompt revascularization. Endovascular techniques offer improved outcomes for this high-mortality condition.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Gastroenterology
Background:
- Mesenteric malperfusion is a rare but serious complication of aortic dissection.
- It is associated with high mortality rates and necessitates urgent intervention to prevent catastrophic outcomes like bowel necrosis and multi-organ failure.
Purpose of the Study:
- To review current management strategies for mesenteric malperfusion in aortic dissection.
- To highlight advances in endovascular techniques and explore promising research for improved treatment pathways.
Main Methods:
- Review of current literature on aortic dissection and mesenteric malperfusion.
- Analysis of endovascular approaches versus traditional surgical methods.
- Discussion of evolving treatment paradigms for Type A and Type B dissections.
Main Results:
- Endovascular techniques have demonstrated improved outcomes and survival compared to traditional open surgical repairs.
- Management strategies for Type A aortic dissection have shifted towards a staged approach involving revascularization before aortic repair.
- Thoracic endovascular aortic repair is now standard for Type B aortic dissection with mesenteric malperfusion.
Conclusions:
- Balancing aortic repair and mesenteric malperfusion treatment remains a clinical challenge.
- Continued research into novel endovascular techniques is crucial for optimizing patient survival and outcomes.
- Refined treatment pathways are essential for managing this complex clinical scenario.
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