Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Behavioral conditioning and experimental motion-induced sickness.

C R Wilpizeski, L D Lowry, U Eyyunni

    American Journal of Otolaryngology
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pneumolabyrinth: a late complication of stapes surgery.

    Ear, nose, & throat journal·2001
    Same author

    Modulation of odor-induced increases in [Ca(2+)](i) by inhibitors of protein kinases A and C in rat and human olfactory receptor neurons.

    Neuroscience·2000
    Same author

    Vagal paraganglioma: the Jefferson experience.

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2000
    Same author

    Leiomyosarcoma of the larynx: diagnosis aided by advances in immunohistochemical staining.

    Ear, nose, & throat journal·2000
    Same author

    Olfactory neuron-specific expression of NeuroD in mouse and human nasal mucosa.

    Cell and tissue research·2000
    Same author

    Clinical impact of sonographically guided biopsy of salivary gland masses and surrounding lymph nodes.

    Ear, nose, & throat journal·2000

    Repeated rotation induced vomiting in squirrel monkeys. Conditioned food aversion developed only with prolonged rotation, questioning its use as a sole indicator of motion sickness in animals.

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Animal Models

    Background:

    • Motion sickness is a common human ailment with complex underlying mechanisms.
    • Understanding animal models is crucial for investigating the neurobehavioral basis of motion sickness.
    • Conditioned responses, such as food aversion, are often used to infer subjective experiences in animals.

    Purpose of the Study:

    • To investigate if repeated sickness-inducing horizontal rotation leads to conditioned emetic responses in squirrel monkeys.
    • To quantify the development of conditioned food aversion and feeding suppression following rotation.
    • To evaluate the validity of conditioned food aversion as an index of motion sickness in animals.

    Main Methods:

    • Adult male squirrel monkeys were exposed to horizontal rotation designed to induce sickness and vomiting.

    Related Experiment Videos

  • Food aversion and feeding suppression were measured based on eating behavior before and after rotation sessions.
  • Rotation duration was varied: some sessions were terminated immediately after the first emetic response, while others lasted 1-2 hours.

    • Main Results:

    • Repeated rotation over ten daily exposures did not result in simple instrumental or classical conditioning of vomiting.
    • Gradual development of conditioned food aversion and feeding suppression occurred when rotation sessions lasted 1-2 hours and induced multiple vomiting bouts.
    • No aversion or feeding suppression was observed if rotation was stopped immediately after the first emetic response.

    Conclusions:

    • Conditioned food aversion and feeding suppression in squirrel monkeys are dependent on the intensity and duration of motion-induced sickness.
    • Classical and instrumental conditioning are insufficient explanations for repeated vomiting episodes during motion exposure.
    • Food aversion alone may not be a reliable indicator of the subjective experience of motion sickness in animal models.