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Updated: May 16, 2025
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Direct Photocatalytic Reductive Amidation of Nitroarenes: A Tandem Reduction-Decarboxylation Approach to Amide Bond
Chenwei Liu1, Xiaowen Qin1, Weiheng Yuan1
1School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Abstract:
We report a photocatalytic strategy for direct amide synthesis from readily available nitroarenes and benzoylformic acids using flavin as an efficient photocatalyst. This one-pot transformation proceeds through a tandem reduction-decarboxylation-amidation sequence under mild blue light irradiation. Preliminary mechanistic studies indicated that nitrosoarene and N-hydroxyamides could be the key intermediates. The method demonstrates a broad substrate scope, excellent functional group tolerance, and remarkable operational simplicity, as it can be conducted under an ambient atmosphere. Notably, this protocol represents a significant advancement in step economy by directly employing diverse nitroarenes as nitrogen sources, avoiding the need for pre-reduced amine intermediates.
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