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Humulus japonicus Enhances Bone Growth and Microarchitecture in Rats: Potential Involvement of IGF-1 Signaling

Seong-Hoo Park1, Jeongjin Park2, Jung-Yoon Yoo3

  • 1Clinical Nutrition Institute, Kyung Hee University, Seoul, Korea.

Journal of Medicinal Food
|May 15, 2025
PubMed
Summary

Humulus japonicus extract supplementation significantly enhanced bone growth and density in rats. This natural agent promotes skeletal development by activating the JAK2/STAT5-IGF-1 pathway, suggesting therapeutic potential for bone health.

Keywords:
Humulus japonicusIGF-1IGFBP-3growth platelongitudinal bone growth

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