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Updated: May 21, 2025

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Targeting processive transcription for Myc-driven circuitry in medulloblastoma.

Lays Martin Sobral1, Faye M Walker1, Krishna Madhavan1

  • 1Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Neuro-Oncology
|May 15, 2025
PubMed
Summary

Targeting CDK9, a dependency in Myc-amplified medulloblastoma (Myc-MB), shows promise. Inhibiting CDK9 and CDK7 disrupts tumor growth programs, offering a new therapeutic strategy for high-risk childhood brain tumors.

Keywords:
CDK7CDK9Mycmedulloblastoma

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