Related Experiment Video
Updated: May 17, 2025
07:02
Application of MassSQUIRM for Quantitative Measurements of Lysine Demethylase Activity
Published on: March 11, 2012
13.3K
Lysine demethylases and cancer
Tomas Eckschlager1, Ales Vicha1, Daniela Frolikova1
1Department of Pediatric Hematology and Oncology, 2nd Medical Faculty, Charles University and University Hospital Motol, V Úvalu 84, Prague 150 06, Czech Republic.
Pathology, Research and Practice
|May 15, 2025
Summary
Lysine demethylases are key epigenetic regulators influencing cancer development and drug resistance. This review synthesizes data on their role in cancer progression and treatment challenges.
Area of Science:
- Molecular Biology
- Epigenetics
- Oncology
Background:
- Epigenetic modifications, particularly histone methylation, are crucial for gene expression and cancer development.
- Histone methylation is regulated by histone methyltransferases and lysine demethylases.
- Lysine demethylases are a diverse group of enzymes impacting various cellular processes and cancer progression.
Purpose of the Study:
- To review the current understanding of lysine demethylases in cancer.
- To focus on the role of lysine demethylases in cancer cell drug resistance.
- To highlight the need for comprehensive expression data across cancer types.
Main Methods:
- Literature review and synthesis of existing data.
- Analysis of the impact of lysine demethylases on oncogenic pathways.
- Investigation of mechanisms by which lysine demethylases contribute to drug resistance.
Main Results:
- Lysine demethylases influence numerous oncogenic pathways.
- Their expression varies significantly across different cancer types.
- They contribute to drug resistance by modulating cell metabolism, stem cell populations, and gene expression.
Conclusions:
- Lysine demethylases are critical players in cancer biology and drug resistance.
- Further research is needed to fully elucidate their expression patterns and therapeutic potential.
- Targeting lysine demethylases may offer novel strategies to overcome cancer drug resistance.
Related Concept Videos
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
02:39lncRNA - Long Non-coding RNAs
8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
01:12Loss of Tumor Suppressor Gene Functions
4.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.7K
03:18Non-LTR Retrotransposons
11.3K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.3K
02:23Abnormal Proliferation
4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K