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Updated: Jul 25, 2026
Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
Oncologic outcomes of microscopic tumor cut through in locally advanced oral squamous cell carcinoma
Guilherme Reimann Agne1, Hugo Fontan Kohler2, Thiago Celestino Chulam2
1Cirurgia de Cabeça e Pescoço no Grupo PESCOP, Balneário Camboriú, SC, Brazil.
Objective:
This study aims to determine the impact of MTCT on local recurrence and disease-specific survival in patients with locally advanced T3-T4 OCSCC and compare it with other clinicopathological variables.
Methods:
A retrospective database analysis of patients diagnosed with locally advanced T3-T4 OCSCC surgically treated and submitted to intraoperative frozen section guiding the margin status. Survival was analyzed using the Kaplan-Meier estimator followed by the Cox model for multivariate analysis.
Results:
We analyzed 475 patients who met inclusion criteria: MTCT occurred in 29 patients (6.11%) and local recurrence was observed in 131 patients (27.6%). MTCT had an impact on univariate (HR = 2.205; 95% CI 1.243-3.914; p = 0.007) and multivariate (HR = 1.851; 95% CI 1.285-2.666; p = 0.001) analyses. Similar results were found for disease-specific survival: univariate (HZ = 1.669; 95% CI 1.056-2.635; p = 0.028) and multivariate (HZ = 1.307; 95% CI 0.816-2.092; p = 0.265) analyses. A total of 231 patients (48.6%) had died of cancer by the end of follow-up. The best predictor for compromised frozen sections was tumor depth of invasion.
Conclusion:
Even after negative final margins, MTCT is an important factor associated with poorer outcome, and treatment intensification should be considered in these patients.
Level Of Evidence:
Level III.
