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Halothane and isoflurane do not decrease PaO2 during one-lung ventilation in intravenously anesthetized patients.

S N Rogers, J L Benumof

    Anesthesia and Analgesia
    |October 1, 1985
    PubMed
    Summary
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    Inhalational anesthetics halothane and isoflurane slightly improved arterial oxygenation during one-lung ventilation in thoracotomy patients. Oxygenation returned to baseline after discontinuing these agents.

    Area of Science:

    • Anesthesiology
    • Cardiopulmonary Physiology

    Background:

    • One-lung ventilation (OLV) is crucial for thoracic surgery but can impair arterial oxygenation.
    • The impact of specific inhalational anesthetics on oxygenation during OLV requires clarification.

    Purpose of the Study:

    • To evaluate the effects of halothane (H) and isoflurane (IF) on arterial oxygenation during OLV in patients undergoing thoracotomy.

    Main Methods:

    • Twenty patients undergoing thoracotomy received intravenous anesthesia initially.
    • Halothane or isoflurane was administered during OLV (PaO2 decreased from 441 to 252 mm Hg).
    • Oxygenation was monitored before, during, and after anesthetic administration and OLV.

    Main Results:

    • Arterial oxygen tension (PaO2) decreased significantly from 441 +/- 64 to 252 +/- 70 mm Hg upon achieving OLV.

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  • Administration of halothane or isoflurane during OLV led to a modest increase in PaO2.
  • PaO2 increased from 258 +/- 72 to 395 +/- 65 mm Hg when two-lung ventilation was resumed.

    • Conclusions:

    • Halothane and isoflurane may offer a slight benefit in maintaining arterial oxygenation during OLV.
    • Further research is needed to fully understand the clinical significance of these findings in thoracic anesthesia.