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Related Experiment Video

Updated: May 22, 2025

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Recent updates in choroidal imaging biomarkers.

Sumit Randhir Singh1, Elham Sadeghi2, Kiran Kumar Vupparaboina2

  • 1Department of Vitreoretina, Akhand Jyoti Eye Hospital, CoE Mastichak, Saran, Bihar, India.

Survey of Ophthalmology
|May 15, 2025
PubMed
Summary
This summary is machine-generated.

Choroidal changes are vital in eye diseases. Advanced imaging techniques now allow detailed qualitative and quantitative analysis of the choroid, aiding clinical understanding.

Keywords:
Choroidal contourChoroidal imaging biomarkersChoroidal thickness, choroidal vascularity indexChoroidal three-dimensional quantificationChoroidal vascular patternsIndocyanine green angiographyLaser doppler holographyVortex vein, optical coherence tomography

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Area of Science:

  • Ophthalmology
  • Retinal Science
  • Vascular Biology

Background:

  • The choroid, a vascular tissue, supports the outer retina and influences eye functions like emmetropization.
  • Choroidal alterations are implicated in various chorioretinal diseases.
  • Recent advancements in optical coherence tomography and indocyanine green angiography have spurred research into the choroid.

Purpose of the Study:

  • To review qualitative and quantitative biomarkers for choroidal analysis.
  • To discuss the principles, clinical applications, and limitations of these biomarkers.
  • To enhance clinical understanding of choroidal changes in health and disease.

Main Methods:

  • Review of advancements in imaging technologies (OCT, ICG angiography).
  • Discussion of qualitative parameters: vascular patterns, vascular wall changes (bulbosity, tortuosity).
  • Discussion of quantitative parameters: choroidal thickness, volume, vascularity index, 3D vessel quantification, blood flow measurement.

Main Results:

  • Imaging technology has evolved from manual to automated methods for choroidal analysis.
  • Qualitative and quantitative biomarkers provide insights into choroidal structure and function.
  • These biomarkers reveal changes in both normal and pathological conditions.

Conclusions:

  • Automated qualitative and quantitative analysis of the choroid is now feasible.
  • Understanding choroidal biomarkers is crucial for diagnosing and managing chorioretinal diseases.
  • This review offers clinicians valuable insights into choroidal physiology and pathology.