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Evaluating monocyte distribution width in pediatric emergency care.

Luisa Agnello1, Caterina Maria Gambino2, Fabio Del Ben3

  • 1Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine, and Clinical Laboratory Medicine, University of Palermo, Palermo, Italy.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 15, 2025
PubMed
Summary
This summary is machine-generated.

Monocyte Distribution Width (MDW) may help identify pediatric infections in the emergency department. While MDW values increase with disease severity, age impacts its diagnostic clarity in children with sepsis.

Keywords:
ChildrenInfectionMDWPediatricSepsis

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Area of Science:

  • Biomarkers in Pediatrics
  • Hematology
  • Infectious Disease Diagnostics

Background:

  • Pediatric sepsis presents diagnostic challenges due to age-related variations.
  • Monocyte Distribution Width (MDW) is a potential sepsis biomarker in adults, but its pediatric utility is unknown.
  • This study investigates MDW's role in diagnosing pediatric infections in the emergency department (ED).

Purpose of the Study:

  • To evaluate the clinical usefulness of Monocyte Distribution Width (MDW) in pediatric patients presenting to the ED.
  • To assess MDW's performance in differentiating infection, sepsis, and shock from controls in children.
  • To explore age-related differences in MDW's diagnostic accuracy.

Main Methods:

  • Retrospective observational study of pediatric patients (<18 years) in the ED.
  • Categorization into controls, infection, sepsis, and shock groups.
  • MDW comparison across groups, stratified by age (≤6 and >6 years), with ROC curve analysis.

Main Results:

  • MDW values generally increased with disease severity, highest in shock.
  • Significant overlap in MDW between infection and sepsis, especially in younger children (≤6 years).
  • MDW showed clearer stepwise increases in older children (>6 years); AUC of 0.73 for infection vs. non-infection.

Conclusions:

  • MDW is an accessible biomarker that can assist in identifying pediatric infections in emergency settings.
  • MDW's diagnostic performance varies with age, showing greater utility in older children.
  • Further research may refine MDW's role in pediatric sepsis diagnostics.