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Serum copper in myocardial infarction--diagnostic and prognostic significance
Insights
Serum copper levels significantly increase in acute myocardial infarction patients, peaking on day 7. Elevated copper may aid in diagnosing and predicting outcomes for myocardial infarction.
Area of Science:
- Cardiology
- Clinical Biochemistry
Background:
- Serum copper is an essential trace element involved in various physiological processes.
- Changes in serum copper levels have been investigated as potential biomarkers for cardiovascular diseases.
Purpose of the Study:
- To investigate the diagnostic and prognostic significance of serum copper levels in acute myocardial infarction (AMI).
- To compare serum copper levels in AMI patients, angina patients, and healthy controls.
Main Methods:
- Serum copper levels were measured in 44 AMI patients, 23 angina patients, and 40 healthy controls.
- Serial measurements were taken to observe changes over 28 days.
- Correlations with cardiac enzyme levels (creatinine phosphokinase and lactic dehydrogenase) were analyzed.
Main Results:
- Serum copper levels were significantly higher in AMI patients compared to angina patients and controls.
- A distinct pattern of rise and fall was observed, peaking on the 7th day post-AMI.
- Complicated AMI cases showed higher serum copper levels, especially on day 28, and significantly higher mean peak levels compared to uncomplicated cases.
- Serial serum copper changes correlated significantly with creatinine phosphokinase and lactic dehydrogenase levels.
Conclusions:
- Serum copper is a valuable biochemical marker for diagnosing acute myocardial infarction.
- The dynamic changes and peak levels of serum copper may offer prognostic insights into AMI outcomes.
- Further research into serum copper's role in cardiovascular disease management is warranted.
Abstract:
Serum copper estimations were carried out in 44 cases of acute myocardial infarction, 23 cases of angina and 40 age and sex matched healthy controls. A highly significant degree of rise in serum copper levels was observed in patients with acute myocardial infarction as compared to cases of angina and controls. The levels showed a gradual rise with peak on 7th day followed by a gradual decline returning to normal on 28th day. The pattern was the same both in complicated and uncomplicated cases except that values were still higher on the 28th day in complicated cases of acute myocardial infarction. Mean peak serum copper levels were significantly higher (p less than .001) in complicated cases of acute myocardial infarction as compared to uncomplicated cases. Significant correlation was found between serial serum copper changes and creatinine phosphokinase and lactic dehydrogenase levels. The prognostic and diagnostic significance of serum copper has been discussed.