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Updated: Jun 14, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Targeting GPX4 palmitoylation to boost antitumor immunity
Daehee Hwang1, Whitney S Henry1
1Department of Biology, Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.
Abstract:
Despite significant milestones in cancer immunotherapy, tumor cells often escape immune surveillance. Zhou et al. revealed that the pivotal ferroptosis suppressor glutathione peroxidase 4 (GPX4) can undergo palmitoylation by zDHHC8, enhancing ferroptosis resistance. This study highlights the potential of targeting GPX4 palmitoylation to enhance cytotoxic T cell-mediated ferroptosis of tumor cells.
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