Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

36
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
36
Renal Clearance01:23

Renal Clearance

492
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
492

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The efficacy and safety of disitamab vedotin plus immunotherapy in locally advanced or metastatic solid tumors: a systematic review and meta-analysis.

Frontiers in immunology·2026
Same author

Efficacy of disitamab vedotin-based therapy in HER2-negative and HER2-low locally advanced or metastatic urothelial carcinoma: A systematic review and meta-analysis.

Urologic oncology·2026
Same author

Ternary Earth-Abundant Catalyst Enabling Stable Silicon Photocathodes for Solar Hydrogen Generation.

ACS applied materials & interfaces·2025
Same author

Serum lactate Dehydrogenase-to-Albumin ratio in upper tract urothelial carcinoma: A promising prognostic biomarker.

BMC urology·2025
Same author

Endoscopic Thulium Laser Ablation with Disitamab Vedotin and Immunotherapy in High-risk Upper Tract Urothelial Carcinoma: A Prospective Pilot Study of a Novel Kidney-sparing Strategy.

European urology oncology·2025
Same author

Trends and projection of pulmonary tuberculosis incidence in Hubei Province, china: an age‒period‒cohort modeling study.

BMC infectious diseases·2025

Related Experiment Video

Updated: May 17, 2025

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

7.6K

Creatinine-Cystatin C Ratio as a Promising Prognostic Biomarker in Patients With UTUC After Radical

Lei Zheng1, Jianjun Ye2, Qihao Wang2

  • 1Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, China; West China School of Medicine, Sichuan University, Chengdu, China; Department of Urology, People's Hospital of Tibet Autonomous Region, Lhasa, China.

Clinical Genitourinary Cancer
|May 15, 2025
PubMed
Summary
This summary is machine-generated.

The preoperative creatinine-cystatin C ratio (CCR) is a key predictor of cancer-specific survival (CSS) in patients undergoing radical nephrectomy (RNU) for upper tract urothelial carcinoma (UTUC). A lower CCR indicates a worse prognosis, aiding treatment decisions.

Keywords:
CCRCancer-specific survivalNomogramPrognosisUpper tract urothelial carcinoma

More Related Videos

Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

21.6K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

13.7K

Related Experiment Videos

Last Updated: May 17, 2025

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

7.6K
Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

21.6K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

13.7K

Area of Science:

  • Urology
  • Oncology
  • Nephrology

Background:

  • Upper tract urothelial carcinoma (UTUC) is a rare malignancy.
  • Radical nephrectomy (RNU) is a standard treatment for UTUC.
  • Predictive markers for treatment outcomes are crucial.

Purpose of the Study:

  • To evaluate the impact of the preoperative creatinine-cystatin C ratio (CCR) on cancer-specific survival (CSS) after RNU for UTUC.
  • To determine if CCR is an independent prognostic factor in UTUC patients.

Main Methods:

  • Retrospective analysis of 504 UTUC patients who underwent RNU.
  • Kaplan-Meier curves and Cox proportional hazards modeling to assess survival and risk.
  • Development and validation of a CCR-based nomogram for CSS prediction.

Main Results:

  • A critical CCR threshold of 59.61 µmol/mg was identified.
  • Lower preoperative CCR correlated with significantly worse CSS.
  • CCR was an independent risk factor for CSS, especially in locally advanced UTUC (pT ≥ 3).
  • The CCR-based nomogram showed strong predictive power (AUC 0.823 for 3-year, 0.793 for 5-year CSS).

Conclusions:

  • Preoperative CCR is a valuable independent predictor of CSS in UTUC patients undergoing RNU.
  • CCR can serve as a useful tool for personalized therapeutic decision-making in UTUC management.